Sami Publishing Company (SPC) Asian Journal of Nanosciences and Materials 2645-775X 2 3 2019 07 01 Synergistic effect of liquid crystals on the additive performance of poly acrylate in lubricating oil 257 270 82345 10.26655/AJNANOMAT.2019.2.3.1 EN Mahua Upadhyay Natural Product and Polymer Chemistry Laboratory, Department of Chemistry, University of North Bengal, Darjeeling-734013, India. Malay Kumar Das Department of Physics, University of North Bengal, Darjeeling-734013, India. R Dąbrowski Institute of Chemistry, Military University of Technology, 00-908 Warsaw, Poland. Pranab Ghosh Natural Product and Polymer Chemistry Laboratory, Department of Chemistry, University of North Bengal, Darjeeling-734013, India. Journal Article 2018 10 17 Multifunctional additive performance of poly acrylate in presence of selective liquid crystal structures were evaluated by standard ASTM methods. Homopolymer of mixed acrylate (octyl, decyl and dodecyl) was synthesised and characterized by thermo gravimetric, spectroscopy and viscometric methods. Additive performances of the polymer were evaluated as viscosity modifier (VM), thickening agent (TA), pour point depressant (PPD) and anti wear (AW) additive. Physical blend of the polymer with six different types of liquid crystals (LC) were also made and evaluated for their performance. The results indicated that all the LC-blended samples act as better VM, PPD, along with excellent AW and thickening performance compare to the pure polymer sample.

Sami Publishing Company (SPC) Asian Journal of Nanosciences and Materials 2645-775X 2 3 2019 07 01 Synthesis and characterization of CaO catalyst obtained from achatina achatina and its application in biodiesel production 271 277 82453 10.26655/AJNANOMAT.2019.2.3.2 EN Oluwatobi O. Amusan Department of Chemistry, University of Ilorin, Ilorin, Kwara State, Nigeria Hitler Louis CAS Key Laboratory for Nanosystem and Hierarchical Fabrication, CAS Centre for Excellence in Nanoscience, National Centre for Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing, China 0000-0002-0286-2865 Adejoke T. Hamzat Department of Chemistry, University of Ilorin, Ilorin, Kwara State, Nigeria Amusan Oluwatobi Omotola Department of Chemistry, University of Ilorin, Ilorin Oluwatomisin Oyebanji Department of Chemistry, University of Ibadan, Ibadan, Oyo State, Nigeria Ayodeji T. Alagbe Department of Chemistry, University of Ilorin, Ilorin, Kwara State, Nigeria Thomas O. Magu CAS Key Laboratory for Green Printing, Institute of Chemistry, University of Chinese Academy of Sciences, 100190 Beijing, China Journal Article 2018 10 07 In this research study, <em>Achatina achatina</em>shells was used as the source of raw material to produce calcium oxide which was used as a catalyst in the production of biodiesel. The main aim of this study was to investigate the effect of varying temperatures on the calcium oxide formed using <em>A. achatina</em> during the calcination process for their possible use as a heterogeneous catalyst in the production of biodiesel. The shells were first grinded and then calcinated at different temperatures ranging from 0 °C to 1000 ^°C. After calcination, the CaCO₃ present in the <em>A. achatina</em>shell was converted to calcium oxide. The obtained calcium oxide was characterized using Fourier transform infrared spectroscopy (FT-IR). The asymmetric stretching of the CO₃^2-(cm^-1) absorption was not proportional with the increasing temperature as it was observed over the plane vibrational modes of CO₃^2-(cm^-1). Also, the O-Hstretching band (cm^-1) at 100 °C and 800 °C had similar absorption values. Pearson correlation revealed both negative and positive relationship between the absorption rate and the temperature, disclosed a significant difference at pA. achatina shell is a suitable catalyst in the production of Biodiesel because it is readily available and has no adverse effect on the environment.

Sami Publishing Company (SPC) Asian Journal of Nanosciences and Materials 2645-775X 2 3 2019 07 01 Thermal decomposition of ammonium perchlorate-commercial nano-TiO2 mixed powder 278 285 82587 10.26655/AJNANOMAT.2019.2.3.3 EN Mostafa Mahinroosta School of Chemical, Petroleum, and Gas Engineering, Iran University of Science and Technology 0000-0001-9709-294 Journal Article 2018 09 11 Thermal decomposition of ammonium perchlorate was improved via addition of transition metals and metal oxides. This work investigates the thermal decomposition of the ammonium perchlorate under the catalytic effect of the commercial nano-TiO₂(nTiO₂). Characterization of nTiO₂showed that its average particle size ranged from 10 to 25 nm with a relatively spherical morphology. Ammonium perchlorate and nTiO₂mixes were prepared by adding three different nTiO₂mass fractionsof 1, 2, and 3 wt% to pure ammonium perchlorate. The results of thermogravimetry analysis revealed that the addition of nTiO₂to pure ammonium perchlorate resulted in a significant decline in its decomposition temperature. The most observed decrease in the decomposition temperature was 61 °C resulted from the addition of 3 wt.% nTiO₂.

Sami Publishing Company (SPC) Asian Journal of Nanosciences and Materials 2645-775X 2 3 2019 07 01 Preparation of different manganese oxide structures via controlling the concentration and the type of the alkaline media 286 300 82588 10.26655/AJNANOMAT.2019.2.3.4 EN Samer Said Egyptian Petroleum Research Institute, Nasr City, Egypt Mary Riad Egyptian Petroleum Research Institute, Nasr City, Egypt Sara Mikhail Egyptian Petroleum Research Institute, Nasr City, Egypt Journal Article 2018 10 01 Birnessite and manganite materials were prepared using a simple precipitation process in an alkaline medium. Potassium hydroxide and tetraethyl ammonium hydroxide (TEAH) used as the precipitating agents. Different techniques such as XRD, DSC, TGA, FT-IR, TEM and N₂ adsorption analyses were employed to characterize the prepared samples. The results revealed that the formed phase in the prepared sample is dependent on the concentration of the precipitating agent. In addition, the XRD results showed the formation of various phases through controlling the concentration of the precipitating agent. Pure phase of birnessite produced in the high alkaline medium, and manganite (γ-MnOOH) at relatively low alkalinity. The samples prepared by using TEAH were well crystalline compared with the analogue one prepared by KOH. The obtained results elaborated the role of TEAH in directing the order of the particles during the preparation step.

Sami Publishing Company (SPC) Asian Journal of Nanosciences and Materials 2645-775X 2 3 2019 07 01 Cyto-toxicity and oligodynamic effect of bio-synthesized silver nanoparticles from plant residue of Artocarpus altilis and its spectroscopic analysis 301 313 82599 10.26655/AJNANOMAT.2019.2.3.5 EN Vasanth Nayagam Department of Botany, Alagappa University, Science Block, Karaikudi-630 003, India Kumaravel Palanisamy Department of Biotechnology, Vysya College, Salem- 636 103.Tamil Nadu, India Dons Thiraviadoss Department of Biotechnology, Vysya College, Salem- 636 103.Tamil Nadu, India Journal Article 2018 12 17 The medicinal plant residue obtained to synthesis AgNPs is the thrust area of research today. The present research work emphasis on the AgNPs synthesized from a medicinal plant residue Artocarpus altilis whose secondary metabolites bear responsible for the confined size of the AgNPs. Further, the AgNPs were analyzed for Physico-chemical analysis, where FT-IR Peak value gives the functional groups of A. altilis. FESEM analyses show surface morphology with 44 nm. EDAX analyses of show metal precursor involved in the process. XRD patterns show the crystalline structure. The AgNPs was analysised for the antibacterial assay against five human pathogens. Finally, cyto-toxic activity of AgNPs was analyzed with two human cancer cell lines namely MCF 7 lung cancer cell line and A549 breast cancer cell line. Hence, the novel and eco-friendly AgNPs are safe with its biocompatibility which becomes a promising agent in the biomedical precisely.

Sami Publishing Company (SPC) Asian Journal of Nanosciences and Materials 2645-775X 2 3 2019 07 01 A smart spproach for delivering of nanosized olanzapine using piper betel biopolymer rate controlling flexi films for transvermillion delivery 314 326 83563 10.26655/AJNANOMAT.2019.2.3.6 EN Nookala Venkala Satheesh Madhav Faculty of Pharmacy, DIT University, Mussorie diversion road, Makkawala Dehradun, Uttarakhand. 248001 Bhavana Singh Faculty of Pharmacy, DIT University, Mussorie diversion road, Makkawala Dehradun, Uttarakhand. 248001 Journal Article 2018 07 03 The aim of the study was to prepare and characterize the nanosize drug loaded bio-flexi films using the novel bioexcipient isolated from the fresh leaves of the <em>piper betle</em> (bioexcipient P) and to explore the potentiality of the lip skin as a novel transvermillion drug delivery system. The bioexcipient prepared using a simplified economical process and was subjected to various physiochemical evaluations along with the spectral analysis including UV, FT-IR, SEM, Mass and ¹H NMR. The nanosized bioflexi film formulated with the novel bioexcipient was screened for its functional properties, such as including filmability. Nanosized olanzapine loaded bioflexi films were formulated by using bioexcipient P as a film former and dextrose as a flexicizer. The formulated nanosized bioflexi films were subjected to various tests such as evaluating the, thickness, folding endurance, swelling index and in vitro release. The size of the nanoparticle was found to be 100 nm. The release of the nanosized olanzapine was maintained over 48 h, which was confirmed in <em>in vitro</em> release experiment. The results revealed that this biopolymer had a promising filmability and bioadhesivity. The formulated nanosized bioflexi films are feasible for delivering the olanzapine by transvermillion administration and for drugs that undergo first-pass metabolism.

Sami Publishing Company (SPC) Asian Journal of Nanosciences and Materials 2645-775X 2 3 2019 07 01 Bio-flexy film formulation for delivery of tiagabine via oro trans-soft palatal route and its in-vitro stability study approach 327 349 84240 10.26655/AJNANOMAT.2019.2.3.7 EN Sugandha Varshney Faculty of Pharmacy, Dit University, Dehradun, 248001, India Nookala Venkala Satheesh Madhav Faculty of Pharmacy, Dit University, Dehradun, 248001, India Journal Article 2018 07 22 <br /><br /><br /> The aim of research work was to formulate bio-flexy films using a novel biopolymer isolated from Rosa polyanthapetals containing tiagabine as a model drug. The soft palate drug delivery helps bypass first-pass metabolism in the liver and pre-systemic elimination in the gastrointestinal tract gets avoided. Tiagabine, anticonvulsant drug possesses t_1/2:7-9 hours (low); protein binding: 96%; water solubility: 22mg/L enhances acts as selective GABA reuptake inhibitor. Side effects include abdominal pain, pharyngitis, suicidal thoughts and sudden unexpected death. Rosa polyantha biopolymer used as bio-excipient due to its biodegradability, biocompatibility, non-toxicity, non-reactiveness on soft palatal surface. Physicochemical characterization of biopolymer displayed inbuilt filmability, mucoadhesivity properties. Bio-flexy films were prepared by solvent casting technique. Formulations containing different ratios of nanosized Tiagabine: Rosa polyantha biopolymer (1:0.5, 1:1; 1:3, 1:5, 1:6, 1:10) (FRT1-FRT6) were prepared and compared with nanosized Tiagabine loaded Sodium CMC standard flexy films (FET1-FET6). The percentage yield of Rosa polyantha biopolymer was found to be 2.24±0.01%. Evaluation parameters for formulations revealed Thickness of nanosized Tiagabine loaded bio-flexy films containing Rosa polyantha biopolymer (FRT1-FRT6): 0.027 mm±0.005 to 0.039±0.004 mm, Folding Endurance: 83-130, Surface pH: 7.00±0.04 to 7.00±0.01, Weight Uniformity: 0.008±0.05 to 0.044±0.03, Drug Content Uniformity: 85.6%±0.48 to 94.8%±0.37, Swelling Percentage: 66%±0.2 to 75%±0.1, Percentage Moisture Uptake (PTU): 2.5%±0.14 to 3.8%±0.10. Mucoadhesivity: 90-1440 mins, Mucoretentivity: 110-240 mins. Drug release pattern for formulations FRT1-FRT6 containing Rosa polyantha biopolymer based on the T50% and T80% was found to be FRT5 (1:6) > FRT4 (1:5) > FRT6 (1:10) > FRT1 (1:0.5)> FRT3 (1:3) > FRT2 (1:1). Based on all above mentioned evaluation parameters, FRT5 (containing Tiagabine: Rosa polyantha biopolymer (1:6)) bio-flexy film having R²= 0.9295, Higuchi Matrix as best fit model, follows Fickian Diffusion (Higuchi Matrix) release mechanism, T50%: 7hrs., T80%: 30 hrs. using BITS Software 1.12 was found to be Best formulation.

Sami Publishing Company (SPC) Asian Journal of Nanosciences and Materials 2645-775X 2 3 2019 07 01 Conductometric study on the benzoic acid in water+methanol systems at different solution temperatures 350 355 85328 10.26655/AJNANOMAT.2019.2.3.8 EN Narasimha Raghavendra Department of Chemistry, K.L.E. society's P. C. Jabin Science College (Autonomous) Vidyanagar, Hubballi-580031 Journal Article 2018 11 27 This research article explores the results of the ion-solvent interaction with the aid of electrical conductivity law of benzoic acid in triple distilled water and different amounts of methanol at 293 K, 303 K, 313 K, and 323 K. The specific conductance obtained from the conductivity meter was examined using Shedlovsky and Kraus-Bray plots. The limiting molar conductance <strong>)</strong> values obtained using the Shedlovsky and Kraus-Bray models. <strong> </strong>values obtained from theShedlovsky and Kraus-Bray models were found to be in good agreement with each other. The association constant (Ka) values obtained from the Shedlovsky plots, whereas dissociation constant (K_d) values obtained from the Kraus-Bray plots. The thermodynamic parameters such as activation energy (E_a), free energy of adsorption (∆G_a), adsorption enthalpy (∆H_a) and adsorption entropy (∆S_a) values are evaluated in order to study the nature of ion-solvent interaction. The negative ∆G_a values showed the spontaneous ion-pair association process

Sami Publishing Company (SPC) Asian Journal of Nanosciences and Materials 2645-775X 2 3 2019 07 01 Novel approaches of treatment via ocusert drug delivery 356 366 85710 10.26655/AJNANOMAT.2019.2.3.9 EN Deepika Sharma Faculty of Pharmacy, DIT University, Makkawala P.O. Bhagwantpur, Dehradun, India, 248009 Shubham Tyagi Faculty of Pharmacy, DIT University, Makkawala P.O. Bhagwantpur, Dehradun, India, 248009 Bhavna Kumar Faculty of Pharmacy, DIT University, Makkawala P.O. Bhagwantpur, Dehradun, India, 248009 Journal Article 2018 12 19 Ocuserts or ophthalmic inserts are “Sterile preparation in the form of solid or semisolid, whose size and shape are specially designed to be applied to the eyes”. The most frequently used dosage forms (ophthalmic solutions and suspensions) are compromised in their effectiveness by several limitations, leading to poor ocular bioavailability. By utilization of the principles of the controlled release as embodied by ocular inserts offers an irritable approach to the problem of prolonging pre-corneal drug residence times. The controlled ocular drug delivery systems increased the efficiency of the drug by enhancing absorption increasing contact time of drug and by reducing drug wastage to the absorption site. Ocuserts were prepared using the solvent casting method. The article discusses about the various structure of the eye, its anatomy with an explanatory diagram. Also, various mechanisms of drug diffusion into an eye with special attention to biological/clinical performances, and potential applications and developments were discussed