eng Sami Publishing Company (SPC) Asian Journal of Nanosciences and Materials 2645-775X 2588-669X 2019-07-01 2 3 257 270 10.26655/AJNANOMAT.2019.2.3.1 82345 مقاله پژوهشی Mahua Upadhyay [email protected] 1 Malay Kumar Das [email protected] 2 R Dąbrowski [email protected] 3 Pranab Ghosh [email protected] 4 Natural Product and Polymer Chemistry Laboratory, Department of Chemistry, University of North Bengal, Darjeeling-734013, India. Department of Physics, University of North Bengal, Darjeeling-734013, India. Institute of Chemistry, Military University of Technology, 00-908 Warsaw, Poland. Natural Product and Polymer Chemistry Laboratory, Department of Chemistry, University of North Bengal, Darjeeling-734013, India. Multifunctional additive performance of poly acrylate in presence of selective liquid crystal structures were evaluated by standard ASTM methods. Homopolymer of mixed acrylate (octyl, decyl and dodecyl) was synthesised and characterized by thermo gravimetric, spectroscopy and viscometric methods. Additive performances of the polymer were evaluated as viscosity modifier (VM), thickening agent (TA), pour point depressant (PPD) and anti wear (AW) additive. Physical blend of the polymer with six different types of liquid crystals (LC) were also made and evaluated for their performance. The results indicated that all the LC-blended samples act as better VM, PPD, along with excellent AW and thickening performance compare to the pure polymer sample. https://www.ajnanomat.com/article_82345_88b71d055dbfa648b290375dc59b7093.pdf Anti wear pour point depressant viscosity modifier multifunctional performances eng Sami Publishing Company (SPC) Asian Journal of Nanosciences and Materials 2645-775X 2588-669X 2019-07-01 2 3 271 277 10.26655/AJNANOMAT.2019.2.3.2 82453 مقاله پژوهشی Oluwatobi O. Amusan 1 Hitler Louis [email protected] 2 Adejoke T. Hamzat 3 Amusan Oluwatobi Omotola [email protected] 4 Oluwatomisin Oyebanji [email protected] 5 Ayodeji T. Alagbe 6 Thomas O. Magu 7 Department of Chemistry, University of Ilorin, Ilorin, Kwara State, Nigeria CAS Key Laboratory for Nanosystem and Hierarchical Fabrication, CAS Centre for Excellence in Nanoscience, National Centre for Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing, China Department of Chemistry, University of Ilorin, Ilorin, Kwara State, Nigeria Department of Chemistry, University of Ilorin, Ilorin Department of Chemistry, University of Ibadan, Ibadan, Oyo State, Nigeria Department of Chemistry, University of Ilorin, Ilorin, Kwara State, Nigeria CAS Key Laboratory for Green Printing, Institute of Chemistry, University of Chinese Academy of Sciences, 100190 Beijing, China In this research study, <em>Achatina achatina</em>shells was used as the source of raw material to produce calcium oxide which was used as a catalyst in the production of biodiesel. The main aim of this study was to investigate the effect of varying temperatures on the calcium oxide formed using <em>A. achatina</em> during the calcination process for their possible use as a heterogeneous catalyst in the production of biodiesel. The shells were first grinded and then calcinated at different temperatures ranging from 0 °C to 1000 ^°C. After calcination, the CaCO₃ present in the <em>A. achatina</em>shell was converted to calcium oxide. The obtained calcium oxide was characterized using Fourier transform infrared spectroscopy (FT-IR). The asymmetric stretching of the CO₃^2-(cm^-1) absorption was not proportional with the increasing temperature as it was observed over the plane vibrational modes of CO₃^2-(cm^-1). Also, the O-Hstretching band (cm^-1) at 100 °C and 800 °C had similar absorption values. Pearson correlation revealed both negative and positive relationship between the absorption rate and the temperature, disclosed a significant difference at pA. achatina shell is a suitable catalyst in the production of Biodiesel because it is readily available and has no adverse effect on the environment. https://www.ajnanomat.com/article_82453_ec37791ed2d8e72379992e0882422343.pdf Achatina achatina Calcium oxide Heterogeneous catalyst Biodiesel eng Sami Publishing Company (SPC) Asian Journal of Nanosciences and Materials 2645-775X 2588-669X 2019-07-01 2 3 278 285 10.26655/AJNANOMAT.2019.2.3.3 82587 مقاله پژوهشی Mostafa Mahinroosta [email protected] 1 School of Chemical, Petroleum, and Gas Engineering, Iran University of Science and Technology Thermal decomposition of ammonium perchlorate was improved via addition of transition metals and metal oxides. This work investigates the thermal decomposition of the ammonium perchlorate under the catalytic effect of the commercial nano-TiO₂(nTiO₂). Characterization of nTiO₂showed that its average particle size ranged from 10 to 25 nm with a relatively spherical morphology. Ammonium perchlorate and nTiO₂mixes were prepared by adding three different nTiO₂mass fractionsof 1, 2, and 3 wt% to pure ammonium perchlorate. The results of thermogravimetry analysis revealed that the addition of nTiO₂to pure ammonium perchlorate resulted in a significant decline in its decomposition temperature. The most observed decrease in the decomposition temperature was 61 °C resulted from the addition of 3 wt.% nTiO₂. https://www.ajnanomat.com/article_82587_6cc339d48dd32ff3c82093c969c7a6ed.pdf Titania Ammonium Perchlorate Thermal decomposition Nanoparticle eng Sami Publishing Company (SPC) Asian Journal of Nanosciences and Materials 2645-775X 2588-669X 2019-07-01 2 3 286 300 10.26655/AJNANOMAT.2019.2.3.4 82588 مقاله پژوهشی Samer Said [email protected] 1 Mary Riad [email protected] 2 Sara Mikhail [email protected] 3 Egyptian Petroleum Research Institute, Nasr City, Egypt Egyptian Petroleum Research Institute, Nasr City, Egypt Egyptian Petroleum Research Institute, Nasr City, Egypt Birnessite and manganite materials were prepared using a simple precipitation process in an alkaline medium. Potassium hydroxide and tetraethyl ammonium hydroxide (TEAH) used as the precipitating agents. Different techniques such as XRD, DSC, TGA, FT-IR, TEM and N₂ adsorption analyses were employed to characterize the prepared samples. The results revealed that the formed phase in the prepared sample is dependent on the concentration of the precipitating agent. In addition, the XRD results showed the formation of various phases through controlling the concentration of the precipitating agent. Pure phase of birnessite produced in the high alkaline medium, and manganite (γ-MnOOH) at relatively low alkalinity. The samples prepared by using TEAH were well crystalline compared with the analogue one prepared by KOH. The obtained results elaborated the role of TEAH in directing the order of the particles during the preparation step. https://www.ajnanomat.com/article_82588_7d2e682b40a0ee072d3afa1b79c55363.pdf Transvermillion Olanzapine Piper betel films Biopolymer eng Sami Publishing Company (SPC) Asian Journal of Nanosciences and Materials 2645-775X 2588-669X 2019-07-01 2 3 301 313 10.26655/AJNANOMAT.2019.2.3.5 82599 مقاله پژوهشی Vasanth Nayagam [email protected] 1 Kumaravel Palanisamy 2 Dons Thiraviadoss 3 Department of Botany, Alagappa University, Science Block, Karaikudi-630 003, India Department of Biotechnology, Vysya College, Salem- 636 103.Tamil Nadu, India Department of Biotechnology, Vysya College, Salem- 636 103.Tamil Nadu, India The medicinal plant residue obtained to synthesis AgNPs is the thrust area of research today. The present research work emphasis on the AgNPs synthesized from a medicinal plant residue Artocarpus altilis whose secondary metabolites bear responsible for the confined size of the AgNPs. Further, the AgNPs were analyzed for Physico-chemical analysis, where FT-IR Peak value gives the functional groups of A. altilis. FESEM analyses show surface morphology with 44 nm. EDAX analyses of show metal precursor involved in the process. XRD patterns show the crystalline structure. The AgNPs was analysised for the antibacterial assay against five human pathogens. Finally, cyto-toxic activity of AgNPs was analyzed with two human cancer cell lines namely MCF 7 lung cancer cell line and A549 breast cancer cell line. Hence, the novel and eco-friendly AgNPs are safe with its biocompatibility which becomes a promising agent in the biomedical precisely. https://www.ajnanomat.com/article_82599_c9b3b9b4b340acc5ff4ae81845169b7d.pdf Cyto-toxic antibacterial Physico-chemical Crystalline Artocarpus altilis eng Sami Publishing Company (SPC) Asian Journal of Nanosciences and Materials 2645-775X 2588-669X 2019-07-01 2 3 314 326 10.26655/AJNANOMAT.2019.2.3.6 83563 مقاله پژوهشی Nookala Venkala Satheesh Madhav [email protected] 1 Bhavana Singh [email protected] 2 Faculty of Pharmacy, DIT University, Mussorie diversion road, Makkawala Dehradun, Uttarakhand. 248001 Faculty of Pharmacy, DIT University, Mussorie diversion road, Makkawala Dehradun, Uttarakhand. 248001 The aim of the study was to prepare and characterize the nanosize drug loaded bio-flexi films using the novel bioexcipient isolated from the fresh leaves of the <em>piper betle</em> (bioexcipient P) and to explore the potentiality of the lip skin as a novel transvermillion drug delivery system. The bioexcipient prepared using a simplified economical process and was subjected to various physiochemical evaluations along with the spectral analysis including UV, FT-IR, SEM, Mass and ¹H NMR. The nanosized bioflexi film formulated with the novel bioexcipient was screened for its functional properties, such as including filmability. Nanosized olanzapine loaded bioflexi films were formulated by using bioexcipient P as a film former and dextrose as a flexicizer. The formulated nanosized bioflexi films were subjected to various tests such as evaluating the, thickness, folding endurance, swelling index and in vitro release. The size of the nanoparticle was found to be 100 nm. The release of the nanosized olanzapine was maintained over 48 h, which was confirmed in <em>in vitro</em> release experiment. The results revealed that this biopolymer had a promising filmability and bioadhesivity. The formulated nanosized bioflexi films are feasible for delivering the olanzapine by transvermillion administration and for drugs that undergo first-pass metabolism. https://www.ajnanomat.com/article_83563_58223f94c9655b9c1e372b376f254979.pdf Transvermillion Olanzapine Piper betel films Biopolymer eng Sami Publishing Company (SPC) Asian Journal of Nanosciences and Materials 2645-775X 2588-669X 2019-07-01 2 3 327 349 10.26655/AJNANOMAT.2019.2.3.7 84240 مقاله پژوهشی Sugandha Varshney [email protected] 1 Nookala Venkala Satheesh Madhav [email protected] 2 Faculty of Pharmacy, Dit University, Dehradun, 248001, India Faculty of Pharmacy, Dit University, Dehradun, 248001, India <br /><br /><br /> The aim of research work was to formulate bio-flexy films using a novel biopolymer isolated from Rosa polyanthapetals containing tiagabine as a model drug. The soft palate drug delivery helps bypass first-pass metabolism in the liver and pre-systemic elimination in the gastrointestinal tract gets avoided. Tiagabine, anticonvulsant drug possesses t_1/2:7-9 hours (low); protein binding: 96%; water solubility: 22mg/L enhances acts as selective GABA reuptake inhibitor. Side effects include abdominal pain, pharyngitis, suicidal thoughts and sudden unexpected death. Rosa polyantha biopolymer used as bio-excipient due to its biodegradability, biocompatibility, non-toxicity, non-reactiveness on soft palatal surface. Physicochemical characterization of biopolymer displayed inbuilt filmability, mucoadhesivity properties. Bio-flexy films were prepared by solvent casting technique. Formulations containing different ratios of nanosized Tiagabine: Rosa polyantha biopolymer (1:0.5, 1:1; 1:3, 1:5, 1:6, 1:10) (FRT1-FRT6) were prepared and compared with nanosized Tiagabine loaded Sodium CMC standard flexy films (FET1-FET6). The percentage yield of Rosa polyantha biopolymer was found to be 2.24±0.01%. Evaluation parameters for formulations revealed Thickness of nanosized Tiagabine loaded bio-flexy films containing Rosa polyantha biopolymer (FRT1-FRT6): 0.027 mm±0.005 to 0.039±0.004 mm, Folding Endurance: 83-130, Surface pH: 7.00±0.04 to 7.00±0.01, Weight Uniformity: 0.008±0.05 to 0.044±0.03, Drug Content Uniformity: 85.6%±0.48 to 94.8%±0.37, Swelling Percentage: 66%±0.2 to 75%±0.1, Percentage Moisture Uptake (PTU): 2.5%±0.14 to 3.8%±0.10. Mucoadhesivity: 90-1440 mins, Mucoretentivity: 110-240 mins. Drug release pattern for formulations FRT1-FRT6 containing Rosa polyantha biopolymer based on the T50% and T80% was found to be FRT5 (1:6) > FRT4 (1:5) > FRT6 (1:10) > FRT1 (1:0.5)> FRT3 (1:3) > FRT2 (1:1). Based on all above mentioned evaluation parameters, FRT5 (containing Tiagabine: Rosa polyantha biopolymer (1:6)) bio-flexy film having R²= 0.9295, Higuchi Matrix as best fit model, follows Fickian Diffusion (Higuchi Matrix) release mechanism, T50%: 7hrs., T80%: 30 hrs. using BITS Software 1.12 was found to be Best formulation. https://www.ajnanomat.com/article_84240_c9664a69386b768abaa66cfd6626ba55.pdf Bio-flexy films nanosized Tiagabine Rosa polyantha biopolymer Soft palatal delivery eng Sami Publishing Company (SPC) Asian Journal of Nanosciences and Materials 2645-775X 2588-669X 2019-07-01 2 3 350 355 10.26655/AJNANOMAT.2019.2.3.8 85328 مقاله پژوهشی Narasimha Raghavendra [email protected] 1 Department of Chemistry, K.L.E. society's P. C. Jabin Science College (Autonomous) Vidyanagar, Hubballi-580031 This research article explores the results of the ion-solvent interaction with the aid of electrical conductivity law of benzoic acid in triple distilled water and different amounts of methanol at 293 K, 303 K, 313 K, and 323 K. The specific conductance obtained from the conductivity meter was examined using Shedlovsky and Kraus-Bray plots. The limiting molar conductance <strong>)</strong> values obtained using the Shedlovsky and Kraus-Bray models. <strong> </strong>values obtained from theShedlovsky and Kraus-Bray models were found to be in good agreement with each other. The association constant (Ka) values obtained from the Shedlovsky plots, whereas dissociation constant (K_d) values obtained from the Kraus-Bray plots. The thermodynamic parameters such as activation energy (E_a), free energy of adsorption (∆G_a), adsorption enthalpy (∆H_a) and adsorption entropy (∆S_a) values are evaluated in order to study the nature of ion-solvent interaction. The negative ∆G_a values showed the spontaneous ion-pair association process https://www.ajnanomat.com/article_85328_bf5d12740ad0a31736055ecbd63c07c8.pdf Electrical conductivity Shedlovsky model Association constant Adsorption free energy Adsorption enthalpy eng Sami Publishing Company (SPC) Asian Journal of Nanosciences and Materials 2645-775X 2588-669X 2019-07-01 2 3 356 366 10.26655/AJNANOMAT.2019.2.3.9 85710 Deepika Sharma [email protected] 1 Shubham Tyagi [email protected] 2 Bhavna Kumar [email protected] 3 Faculty of Pharmacy, DIT University, Makkawala P.O. Bhagwantpur, Dehradun, India, 248009 Faculty of Pharmacy, DIT University, Makkawala P.O. Bhagwantpur, Dehradun, India, 248009 Faculty of Pharmacy, DIT University, Makkawala P.O. Bhagwantpur, Dehradun, India, 248009 Ocuserts or ophthalmic inserts are “Sterile preparation in the form of solid or semisolid, whose size and shape are specially designed to be applied to the eyes”. The most frequently used dosage forms (ophthalmic solutions and suspensions) are compromised in their effectiveness by several limitations, leading to poor ocular bioavailability. By utilization of the principles of the controlled release as embodied by ocular inserts offers an irritable approach to the problem of prolonging pre-corneal drug residence times. The controlled ocular drug delivery systems increased the efficiency of the drug by enhancing absorption increasing contact time of drug and by reducing drug wastage to the absorption site. Ocuserts were prepared using the solvent casting method. The article discusses about the various structure of the eye, its anatomy with an explanatory diagram. Also, various mechanisms of drug diffusion into an eye with special attention to biological/clinical performances, and potential applications and developments were discussed https://www.ajnanomat.com/article_85710_0dfe8d22269344ab49c91e38b9f8e429.pdf Ocuserts Eye Ocular inserts Sterile